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Ignacio E León Selected Research

Copper

3/2024Promising Dual Anticancer and Antimetastatic Action by a Cu(II) Complex Derived from Acylhydrazone on Human Osteosarcoma Models.
12/2023New copper(II) and oxidovanadium(IV) complexes with a vitamin B6 Schiff base: mechanism of action and synergy studies on 2D and 3D human osteosarcoma cell models.
4/2023Finding New Molecular Targets of Two Copper(II)-Hydrazone Complexes on Triple-Negative Breast Cancer Cells Using Mass-Spectrometry-Based Quantitative Proteomics.
1/2023Copper Complexes as Antitumor Agents: In vitro and In vivo Evidence.
2/2022Antiproliferative activity of two copper (II) complexes on colorectal cancer cell models: Impact on ROS production, apoptosis induction and NF-κB inhibition.
7/2021Anticancer activity of a new copper(II) complex with a hydrazone ligand. Structural and spectroscopic characterization, computational simulations and cell mechanistic studies on 2D and 3D breast cancer cell models.
1/2020Anticancer and antimetastatic activity of copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres.

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Ignacio E León Research Topics

Disease

16Neoplasms (Cancer)
03/2024 - 12/2016
10Osteosarcoma (Osteogenic Sarcoma)
03/2024 - 01/2016
5Breast Neoplasms (Breast Cancer)
08/2023 - 01/2020
2Bone Neoplasms (Bone Cancer)
12/2023 - 12/2020
2Triple Negative Breast Neoplasms
10/2023 - 04/2023
2Colonic Neoplasms (Colon Cancer)
08/2023 - 03/2023
2Colorectal Neoplasms (Colorectal Cancer)
02/2022 - 09/2019
1Necrosis
12/2023
1Lung Neoplasms (Lung Cancer)
01/2023

Drug/Important Bio-Agent (IBA)

8Cisplatin (Platino)FDA LinkGeneric
10/2023 - 01/2019
7CopperIBA
03/2024 - 01/2020
3LigandsIBA
12/2023 - 12/2016
3PlatinumIBA
10/2023 - 08/2021
2GoldIBA
12/2023 - 10/2023
2Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2023 - 08/2021
2Antineoplastic Agents (Antineoplastics)IBA
10/2023 - 01/2023
2HydrazonesIBA
04/2023 - 07/2021
2DNA (Deoxyribonucleic Acid)IBA
01/2022 - 07/2021
2Clioquinol (Vioform)FDA Link
12/2020 - 01/2017
2oxovanadium IVIBA
01/2017 - 01/2016
2chrysinIBA
12/2016 - 01/2016
2FlavonoidsIBA
12/2016 - 01/2016
1Schiff Bases (Schiff Base)IBA
12/2023
1Sorafenib (BAY 43-9006)FDA Link
12/2023
1Vitamin B 6IBA
12/2023
1Auranofin (Ridaura)FDA Link
12/2023
1Gold CompoundsIBA
12/2023
1ThiosemicarbazonesIBA
12/2023
1AntioxidantsIBA
11/2022
1IonsIBA
11/2022
1MetalsIBA
11/2022
1bis(1,10-phenanthroline)copper(2+) ionIBA
02/2022
1copper(I) bis(2,9-dimethyl-1,10-phenanthroline)IBA
02/2022
1Proteins (Proteins, Gene)FDA Link
01/2022
1Focal Adhesion Protein-Tyrosine KinasesIBA
01/2022
1Proteasome Endopeptidase Complex (Proteasome)IBA
01/2022
1Carboplatin (JM8)FDA LinkGeneric
08/2021
1Matrix Metalloproteinases (MMPs)IBA
12/2020
1TropoloneIBA
01/2020
1Metalloproteases (Metalloproteinases)IBA
01/2020
1bis(4,7- dimethyl- 1,10- phenanthroline)sulfatooxovanadium(IV)IBA
09/2019
1PhenanthrolinesIBA
09/2019
1SurvivinIBA
08/2019
1Ruthenium CompoundsIBA
01/2019

Therapy/Procedure

4Drug Therapy (Chemotherapy)
03/2024 - 08/2021
2Therapeutics
01/2022 - 07/2020